r-dsb

Normalize & denoise droplet single cell protein data (CITE-Seq)

R-dsb improves protein expression analysis in droplet-based single-cell studies. The package specifically addresses noise in raw protein UMI counts from methods like CITE-seq. It identifies and removes two main sources of noise—protein-specific noise from unbound antibodies and droplet/cell-specific noise. The package is applicable to various methods, including CITE-seq, REAP-seq, ASAP-seq, TEA-seq, and Mission Bioplatform data. Check the vignette for tutorials on integrating dsb with Seurat and Bioconductor, and using dsb in Python.

Versions: 1.0.4
Website: https://github.com/niaid/dsb
Licenses: CC0
Package source: gnu/packages/bioconductor.scm
Builds: See build status
Issues: See known issues

Installation

Install the latest version of r-dsb as follows:

guix install r-dsb

Or install a particular version:

guix install r-dsb@1.0.4

You can also install packages in augmented, pure or containerized environments for development or simply to try them out without polluting your user profile. See the guix shell documentation for more information.

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